Research workbench
Rfviiifc-vwf-xten (BIVV001)
Analyse Rfviiifc-vwf-xten (BIVV001) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KWO
- Type
- protein
- Length
- 1,678 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coagulation factor fviii-Fc-xten; Von willebrand factor-xten-Fc
- Ligands
- NAG, BMA, CA, ZN, CU
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 10% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coagulation factor fviii-Fc-xten | protein | 1200 | 8% helix, 44% strand | — |
| V | Von willebrand factor-xten-Fc | protein | 478 | 14% helix, 32% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, V
- BMA · beta-D-mannopyranose · sugar
- CA · Calcium ion · metal · 2 copies · chains A, V
- ZN · Zinc ion · metal · chains A
- CU · Copper (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 825 | 0.86 | 0.89 | 87 | empty |
| 2 | 905 | 0.79 | 0.82 | 93 | empty |
| 3 | 1036 | 0.74 | 0.77 | 130 | empty |
| 4 | 60 | 0.68 | 0.96 | 24 | empty |
| 5 | 601 | 0.68 | 0.77 | 51 | empty |
Interfaces
1 interface between chains.
- A–V · 2568 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 disulfide, 4 glycan, 1 modified (disulfide, N-glycosylation, sulfation).
Compared structures
- 7KWO · rFVIIIFc-VWF-XTEN (BIVV001) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KWO · PDBe 7KWO
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