Research workbench
Binary complex of tert (telomerase reverse transcriptase) with RNA/TELOMERIC DNA hybrid
Analyse Binary complex of tert (telomerase reverse transcriptase) with RNA/TELOMERIC… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KQM
- Type
- protein + DNA + RNA
- Length
- 628 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase; RNA (5'-R(*AP*UP*CP*CP*AP*GP*GP*UP*GP*CP*AP*C)…
- EC
- 2.7.7.49
- UniProt
- Q0QHL8
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 596 | 50% helix, 13% strand | Q0QHL8 |
| B | RNA (5'-R(*AP*UP*CP*CP*AP*GP*GP*UP*GP*CP*AP*C)- D(P*AP*AP*AP*GP*AP*A)-3') | rna | 17 | — | — |
| C | DNA (5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*GP*CP*AP*CP*CP*TP*G)- 3') | dna | 15 | — | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 7 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1115 | 0.78 | 0.80 | 96 | EDO |
| 2 | 856 | 0.75 | 0.79 | 57 | empty |
| 3 | 83 | 0.71 | 0.95 | 22 | empty |
| 4 | 432 | 0.70 | 0.81 | 46 | empty |
| 5 | 273 | 0.58 | 0.78 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–B · 789 Ų buried · 9 hydrogen bonds · protein-nucleic
- B–C · 697 Ų buried · 68 hydrogen bonds · nucleic-nucleic
- A–C · 665 Ų buried · 9 hydrogen bonds · protein-nucleic
Compared structures
- 7KQM · Binary complex of TERT (telomerase reverse transcriptase) with RNA/telomeric DNA hybrid · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0QHL8
- Elsewhere: RCSB PDB 7KQM · PDBe 7KQM · UniProt Q0QHL8
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