Research workbench
PCNA bound to truncated peptide mimetic
Analyse PCNA bound to truncated peptide mimetic in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KQ1
- Type
- protein
- Length
- 816 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear antigen; Lys-arg-arg-gln-thr-ser-met-thr-asp-phe-tyr-his-ser-ly…
- UniProt
- P12004
- Pockets
- 6 · best druggability 0.50
Structure
x-ray diffraction · 4 distinct chains · 17% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Proliferating cell nuclear antigen | protein | 257 | 17% helix, 47% strand | P12004 |
| B, D | Lys-arg-arg-gln-thr-ser-met-thr-asp-phe-tyr-his-ser-lys- arg | protein | 15 | 20% helix, 27% strand | — |
| E | Proliferating cell nuclear antigen | protein | 259 | 17% helix, 45% strand | P12004 |
| F | Lys-arg-arg-gln-thr-ser-met-thr-asp-phe-tyr-his-ser-lys- arg | protein | 13 | 23% helix, 23% strand | — |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.50 | 0.81 | 29 | empty |
| 2 | 85 | 0.43 | 0.79 | 18 | empty |
| 3 | 92 | 0.38 | 0.76 | 22 | empty |
| 4 | 74 | 0.38 | 0.78 | 17 | empty |
| 5 | 70 | 0.31 | 0.74 | 20 | empty |
Interfaces
6 interfaces between chains.
- A–B · 875 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 867 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 755 Ų buried · 11 hydrogen bonds · protein-protein
- C–E · 747 Ų buried · 16 hydrogen bonds · protein-protein
- A–E · 743 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7KQ1 · PCNA bound to truncated peptide mimetic · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12004
- Elsewhere: RCSB PDB 7KQ1 · PDBe 7KQ1 · UniProt P12004
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