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SARM1 octamer

Analyse SARM1 octamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KNQ
Type: protein
Length: 4,704 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NAD(+) hydrolase SARM1
EC: 3.2.2.6, 3.2.2.-
UniProt: Q6SZW1
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 51% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	NAD(+) hydrolase SARM1 (EC 3.2.2.6, 3.2.2.-)	protein	588	51% helix, 3% strand	Q6SZW1

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	863	0.83	0.85	93	empty
2	458	0.78	0.86	61	empty
3	147	0.77	0.95	23	empty
4	162	0.77	0.94	28	empty
5	443	0.77	0.86	54	empty

Interfaces

8 interfaces between chains.

G–H · 1966 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 1958 Å² buried · 14 hydrogen bonds · protein-protein
A–F · 1957 Å² buried · 16 hydrogen bonds · protein-protein
D–E · 1954 Å² buried · 16 hydrogen bonds · protein-protein
F–G · 1950 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7KNQ · SARM1 Octamer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6SZW1
Elsewhere: RCSB PDB 7KNQ · PDBe 7KNQ · UniProt Q6SZW1

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