UniProt Q6SZW1
NAD(+) hydrolase SARM1 (Q6SZW1)
NAD(+) hydrolase SARM1 (UniProt Q6SZW1), EC 3.2.2.-, 3.2.2.6: 33 experimental structures on GenesisL1, 10 ligands bound, 48 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q6SZW1
- Protein
- NAD(+) hydrolase SARM1
- EC
- 3.2.2.-, 3.2.2.6
- Experimental structures
- 33
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 48 · 3 records with a druggable one
Structures
33 records of Q6SZW1 in the MolNFT archive: 33 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6O0Q | Crystal structure of the tir domain from human SARM1 in complex with ribose | x-ray diffraction | A, B | BDR, CL | — |
| 6O0R | Crystal structure of the tir domain from human SARM1 in complex with glycerol | x-ray diffraction | A, B | — | — |
| 6O0S | Crystal structure of the tandem SAM domains from human SARM1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6O0T | Crystal structure of selenomethionine labelled tandem SAM domains (L446M:L505M:L523M mutant) from… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6O0U | Crystal structure of the tir domain H685A mutant from human SARM1 | x-ray diffraction | A, B | — | — |
| 6O0V | Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 2 | x-ray diffraction | A, B, C, D | CL | 4 (best 0.75) |
| 6O0V | Crystal structure of the tir domain G601P mutant from human SARM1, crystal form 2 | x-ray diffraction | A, B, C, D | CL | — |
| 6O1B | Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 1 | x-ray diffraction | A | — | 1 (best 0.42) |
| 6O1B | Crystal structure of the tir domain G601P mutant from human SARM1, crystal form 1 | x-ray diffraction | A | — | — |
| 6QWV | SARM1 SAM1-2 domains | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 6WPK | SARM1 autoinhibited conformation | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 6ZFX | HSARM1 grafix-ed | electron microscopy | A, B, C, D, E, F, G, H | S1N | — |
| 6ZG0 | SARM1 SAM1-2 domains | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 6ZG1 | SARM1 SAM1-2 domains | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7ANW | hSARM1 NAD+ complex | electron microscopy | A, B, C, D, E, F, G, H | NAD | 20 (best 0.84) |
| 7ANW | HSARM1 NAD+ complex | electron microscopy | A, B, C, D, E, F, G, H | NAD | — |
| 7CM5 | Full-length Sarm1 in a self-inhibited state | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7CM5 | Full-length SARM1 in a self-inhibited state | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7CM6 | NAD+-bound SARM1 in the self-inhibited state | electron microscopy | A, B, C, D, E, F, G, H | NAD | — |
| 7CM7 | NAD+-bound SARM1 E642A in the self-inhibited state | electron microscopy | A, B, C, D, E, F, G, H | NAD | — |
| 7DJT | Human SARM1 inhibitory state bounded with inhibitor dHNN | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7DJT | Human SARM1 inhibitory state bounded with inhibitor dhnn | electron microscopy | A, B, C, D, E, F, G, H | O | — |
| 7KNQ | SARM1 octamer | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7LD0 | Cryo-EM structure of ligand-free human SARM1 | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7NAG | Crystal structure of the TIR domain from human SARM1 in complex with 1AD | x-ray diffraction | A, B | 1QD | 3 (best 0.40) |
| 7NAG | Crystal structure of the tir domain from human SARM1 in complex with 1AD | x-ray diffraction | A, B | 1QD | — |
| 7NAH | Crystal structure of the tir domain from human SARM1 in complex with 2AD | x-ray diffraction | A, B | 1OF | — |
| 7NAI | Crystal structure of the tir domain from human SARM1 in complex with 3AD | x-ray diffraction | A, B | 1O4 | — |
| 7NAJ | Crystal structure of the tir domain from human SARM1 in complex with ara-2'F-adpr | x-ray diffraction | A, B | 1LK | — |
| 7NAK | Cryo-EM structure of activated human SARM1 in complex with nmn and 1AD (TIR:1AD) | electron microscopy | D, C, G, B, A, E, F, H | 1QD | — |
| 7NAL | Cryo-EM structure of activated human SARM1 in complex with nmn and 1AD (arm and SAM domains) | electron microscopy | A, B, C, D, E, F, G, H | NMN | — |
| 8GQ5 | Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | 20 (best 0.78) |
| Q6SZW1 | AlphaFold monomer V2.0 prediction for NAD(+) hydrolase SARM1 (Q6SZW1) | — | — | — |
Ligands
- NAD · Nicotinamide-adenine-dinucleotide · in 4 records
- 1QD · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate · in 3 records
- CL · Chloride ion · in 3 records
- 1LK · 1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-D-arabinitol · in 1 record
- 1O4 · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate · in 1 record
- 1OF · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(8-oxidanylidene-7~{H}-2,7-naphthyridin-2-yl)oxolan-2-yl]methyl hydrogen phosphate · in 1 record
- BDR · Beta-D-ribofuranose · in 1 record
- NMN · Beta-nicotinamide ribose monophosphate · in 1 record
- O · Oxygen atom · in 1 record
- S1N · (~{E})-4-methylnon-4-enedial · in 1 record
Elsewhere
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