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Wild-type epi-isozizaene synthase: complex with 3 MG2+ and pamidronate

Analyse Wild-type epi-isozizaene synthase: complex with 3 MG2+ and pamidronate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KJ8
Type: protein
Length: 340 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epi-isozizaene synthase
EC: 4.2.3.37
UniProt: A0A6M9XZI2
Ligands: 210, MG, SO4
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epi-isozizaene synthase (EC 4.2.3.37)	protein	340	76% helix, 0% strand	A0A6M9XZI2

Ligands and binding sites

210 · Pamidronate · ligand · chains A
MG · Magnesium ion · metal · 3 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.81	0.97	27	MG, 210
2	54	0.67	0.96	18	empty
3	69	0.43	0.81	15	empty
4	53	0.35	0.79	11	empty
5	83	0.34	0.74	16	empty

Compared structures

7KJ8 · Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and pamidronate · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6M9XZI2
Elsewhere: RCSB PDB 7KJ8 · PDBe 7KJ8 · UniProt A0A6M9XZI2

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