Research workbench
Salivary protein from culex quinquefasciatus that belongs to the cysteins and tryptophan-rich (cwrc) family
Analyse Salivary protein from culex quinquefasciatus that belongs to the cysteins and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KC8
- Type
- protein
- Length
- 559 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 16.4 kda salivary peptide
- UniProt
- Q6TS05
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 16.4 kda salivary peptide | protein | 140 | 0% helix, 49% strand | Q6TS05 |
| C | 16.4 kda salivary peptide | protein | 138 | 0% helix, 50% strand | Q6TS05 |
| D | 16.4 kda salivary peptide | protein | 141 | 0% helix, 48% strand | Q6TS05 |
Ligands and binding sites
- ACY · Acetic acid · additive · 3 copies · chains A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 833 | 0.70 | 0.76 | 103 | ACY |
| 2 | 438 | 0.68 | 0.79 | 69 | empty |
| 3 | 239 | 0.51 | 0.76 | 35 | empty |
Interfaces
6 interfaces between chains.
- C–D · 397 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 388 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 266 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 173 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 165 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 7KC8 · Salivary protein from Culex quinquefasciatus that belongs to the Cysteins and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6TS05
- Elsewhere: RCSB PDB 7KC8 · PDBe 7KC8 · UniProt Q6TS05
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