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Aldolase, rabbit muscle (beam-tilt refinement X4)

Analyse Aldolase, rabbit muscle (beam-tilt refinement X4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KA4
Type: protein
Length: 1,372 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-bisphosphate aldolase a
EC: 4.1.2.13
UniProt: P00883
Pockets: 15 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 47% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D	Fructose-bisphosphate aldolase a (EC 4.1.2.13)	protein	343	47% helix, 16% strand	P00883

Pockets

15 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	523	0.83	0.89	68	empty
2	850	0.80	0.82	105	empty
3	287	0.77	0.89	42	empty
4	89	0.74	0.97	32	empty
5	370	0.73	0.84	51	empty

Interfaces

6 interfaces between chains.

B–D · 1286 Å² buried · 27 hydrogen bonds · protein-protein
A–C · 1233 Å² buried · 26 hydrogen bonds · protein-protein
C–D · 1152 Å² buried · 13 hydrogen bonds · protein-protein
B–A · 1148 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 27 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7KA4 · Aldolase, rabbit muscle (beam-tilt refinement x4) · the same entry in another collection · chain D against D, TM-score 1.00
P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00883
Elsewhere: RCSB PDB 7KA4 · PDBe 7KA4 · UniProt P00883

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