Research workbench

Aldolase, rabbit muscle (beam-tilt refinement X2)

Analyse Aldolase, rabbit muscle (beam-tilt refinement X2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7KA2
Type: protein
Length: 1,372 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-bisphosphate aldolase a
EC: 4.1.2.13
UniProt: P00883
Pockets: 15 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D	Fructose-bisphosphate aldolase a (EC 4.1.2.13)	protein	343	48% helix, 16% strand	P00883

Pockets

15 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	370	0.83	0.92	51	empty
2	876	0.80	0.82	98	empty
3	296	0.77	0.89	47	empty
4	287	0.76	0.89	44	empty
5	131	0.73	0.93	36	empty

Interfaces

6 interfaces between chains.

B–D · 1420 Å² buried · 23 hydrogen bonds · protein-protein
A–C · 1255 Å² buried · 18 hydrogen bonds · protein-protein
C–D · 1099 Å² buried · 13 hydrogen bonds · protein-protein
B–A · 1080 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 24 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7KA2 · Aldolase, rabbit muscle (beam-tilt refinement x2) · the same entry in another collection · chain D against D, TM-score 1.00
P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00883
Elsewhere: RCSB PDB 7KA2 · PDBe 7KA2 · UniProt P00883

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.