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Cryoem structure of a trehalose monomycolate transporter in lipid nanodiscs

Analyse Cryoem structure of a trehalose monomycolate transporter in lipid nanodiscs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7K8C
Type: protein
Length: 723 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trehalose monomycolate exporter MMPL3
UniProt: A0QP27
Pockets: 16 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 65% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trehalose monomycolate exporter MMPL3	protein	723	65% helix, 5% strand	A0QP27

Pockets

16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	908	0.85	0.86	88	empty
2	205	0.81	0.94	33	empty
3	140	0.76	0.94	24	empty
4	515	0.75	0.82	67	empty
5	94	0.74	0.95	20	empty

Compared structures

7K8C · CryoEM structure of a trehalose monomycolate transporter in lipid nanodiscs · the same entry in another collection · chain A against A, TM-score 1.00
A0QP27 · AlphaFold monomer V2.0 prediction for trehalose monomycolate exporter MMPL3 (A0QP27) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0QP27
Elsewhere: RCSB PDB 7K8C · PDBe 7K8C · UniProt A0QP27

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