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Crystal structure of PAC1R in complex with peptide antagonist

Analyse Crystal structure of PAC1R in complex with peptide antagonist in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7JQD
Type: protein
Length: 123 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pituitary adenylate cyclase-activating polypeptide type I receptor; Peptide-43
UniProt: P41586
Ligands: NH2

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pituitary adenylate cyclase-activating polypeptide type I receptor	protein	85	34% helix, 25% strand	P41586
B	Peptide-43	protein	38	84% helix, 0% strand	—

Ligands and binding sites

NH2 · Amino group · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 937 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

7JQD · Crystal Structure of PAC1r in complex with peptide antagonist · the same entry in another collection · chain A against A, TM-score 1.00
P41586 · AlphaFold monomer V2.0 prediction for pituitary adenylate cyclase- activating polypeptide… · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41586
Elsewhere: RCSB PDB 7JQD · PDBe 7JQD · UniProt P41586

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