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Solution structure of the pleckstrin homology domain of human protein kinase B beta (PKB/AKT)

Analyse Solution structure of the pleckstrin homology domain of human protein kinase B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1P6S
Type: protein
Length: 111 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rac-beta SERINE/THREONINE protein kinase
EC: 2.7.1.-
UniProt: P31751
Pockets: 1 · best druggability 0.47

Structure

solution nmr · 1 distinct chain · 16% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rac-beta SERINE/THREONINE protein kinase (EC 2.7.1.-)	protein	111	16% helix, 36% strand	P31751

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.47	0.84	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1P6S · Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta… · the same entry in another collection · chain A against A, TM-score 1.00
P31751 · AlphaFold monomer V2.0 prediction for rac-beta SERINE/THREONINE- protein kinase (P31751) · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31751
Elsewhere: RCSB PDB 1P6S · PDBe 1P6S · UniProt P31751

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