Research workbench
Structural basis for variation in adenovirus affinity for the cellular receptor car (S489Y mutant)
Analyse Structural basis for variation in adenovirus affinity for the cellular receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1P6A
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fiber protein; Coxsackievirus and adenovirus receptor
- UniProt
- P36711, P78310
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fiber protein | protein | 185 | 10% helix, 41% strand | P36711 |
| B | Coxsackievirus and adenovirus receptor | protein | 124 | 7% helix, 47% strand | P78310 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.44 | 0.75 | 19 | empty |
| 2 | 155 | 0.43 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 821 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1P6A · Structural basis for variation in adenovirus affinity for the cellular receptor car… · the same entry in another collection · chain A against A, TM-score 1.00
- P78310 · AlphaFold monomer V2.0 prediction for coxsackievirus and adenovirus receptor (P78310) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36711
- Every structure of UniProt P78310
- Elsewhere: RCSB PDB 1P6A · PDBe 1P6A · UniProt P36711 · UniProt P78310
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.