Research workbench
Structure of porcine insulin cocrystallized with clupeine Z
Analyse Structure of porcine insulin cocrystallized with clupeine Z in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7INS
- Type
- protein
- Length
- 169 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin (chain a); Insulin (chain B); General protamine chain
- UniProt
- P01315
- Ligands
- CRS, UNK, ZN
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Insulin (chain a) | protein | 21 | 62% helix, 5% strand | P01315 |
| B, D, F | Insulin (chain B) | protein | 30 | 70% helix, 3% strand | P01315 |
| G | General protamine chain | protein | 16 | 0% helix, 0% strand | — |
Ligands and binding sites
- CRS · M-cresol · ligand · 3 copies · chains A, B, D, G, C, F, E
- UNK · Unknown · ligand · 2 copies · chains D, F, C, G
- ZN · Zinc ion · metal · chains B, D, F, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.51 | 0.83 | 15 | CRS, UNK |
| 2 | 74 | 0.50 | 0.84 | 15 | CRS |
| 3 | 94 | 0.50 | 0.82 | 23 | CRS |
Interfaces
15 interfaces between chains.
- B–G · 699 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 607 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 605 Ų buried · 5 hydrogen bonds · protein-protein
- E–F · 605 Ų buried · 2 hydrogen bonds · protein-protein
- D–G · 525 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 7INS · Structure of porcine insulin cocrystallized with clupeine Z · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01315
- Elsewhere: RCSB PDB 7INS · PDBe 7INS · UniProt P01315
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.