Research workbench
Alpha-1,2-GLUCOSYLTRANSFERASE_UDP_SUCROSE_TLL1591
Analyse Alpha-1,2-GLUCOSYLTRANSFERASE_UDP_SUCROSE_TLL1591 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7FGA
- Type
- protein
- Length
- 1,376 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycosyl transferase
- UniProt
- Q8DIJ4
- Ligands
- UDP, Z9N, GLC
- Pockets
- 11 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glycosyl transferase | protein | 344 | 34% helix, 11% strand | Q8DIJ4 |
| B, D | Glycosyl transferase | protein | 344 | 37% helix, 14% strand | Q8DIJ4 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · 4 copies · chains A, B, C, D
- Z9N · alpha-D-fructofuranose · sugar · 4 copies · chains A, B, C, D
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1007 | 0.82 | 0.83 | 93 | empty |
| 2 | 1118 | 0.81 | 0.82 | 138 | Z9N, GLC, UDP |
| 3 | 740 | 0.76 | 0.81 | 74 | Z9N, GLC, UDP |
| 4 | 677 | 0.75 | 0.81 | 55 | Z9N, GLC, UDP |
| 5 | 664 | 0.75 | 0.81 | 53 | Z9N, GLC, UDP |
Interfaces
5 interfaces between chains.
- B–D · 635 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 587 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 564 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 229 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 59 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7FGA · Alpha-1,2-glucosyltransferase_UDP_sucrose_tll1591 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DIJ4
- Elsewhere: RCSB PDB 7FGA · PDBe 7FGA · UniProt Q8DIJ4
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