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Osmium-bound human serum transferrin

Analyse Osmium-bound human serum transferrin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7FFU
Type: protein
Length: 649 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serotransferrin
UniProt: P02787
Ligands: FE, OS
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serotransferrin	protein	649	36% helix, 20% strand	P02787

Ligands and binding sites

FE · Fe (III) ion · metal · chains A
OS · Osmium ion · metal · chains A
MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	859	0.78	0.81	83	MLI
2	665	0.76	0.82	53	empty
3	181	0.56	0.80	20	empty
4	133	0.40	0.74	27	empty
5	76	0.33	0.74	15	empty

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

7FFU · Osmium-bound human serum transferrin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02787
Elsewhere: RCSB PDB 7FFU · PDBe 7FFU · UniProt P02787

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