GL1X · GenesisL1 explorer

Research workbench

Human ntcp in complex with YN69083 Fab

Analyse Human ntcp in complex with YN69083 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7FCI
Type
protein
Length
734 residues
Chains
3
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
SODIUM/BILE acid cotransporter; Fab light chain; Fab heavy chain
UniProt
Q14973
Pockets
11 · best druggability 0.76

Structure

electron microscopy · 3 distinct chains · 36% helix, 30% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ASODIUM/BILE acid cotransporterprotein29780% helix, 1% strandQ14973
LFab light chainprotein2137% helix, 48% strand—
HFab heavy chainprotein2246% helix, 51% strand—

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
110370.760.7885empty
2890.530.8431empty
32450.510.7530empty
42320.510.7638empty
5740.450.8118empty

Interfaces

3 interfaces between chains.

  • L–H · 1945 Ų buried · 17 hydrogen bonds · protein-protein
  • A–H · 923 Ų buried · 4 hydrogen bonds · protein-protein
  • A–L · 488 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

  • 7FCI · human NTCP in complex with YN69083 Fab · the same entry in another collection · chain A against A, TM-score 1.00
  • Q14973 · AlphaFold monomer V2.0 prediction for SODIUM/BILE acid cotransporter (Q14973) · a predicted model of the same protein · chain A against A, TM-score 0.79

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.