Research workbench
Circular permutation of helix a in T4 lysozyme
Analyse Circular permutation of helix a in T4 lysozyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1P5C
- Type
- protein
- Length
- 664 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysozyme
- EC
- 3.2.1.17
- UniProt
- P00720
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 63% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Lysozyme (EC 3.2.1.17) | protein | 166 | 63% helix, 9% strand | P00720 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 708 | 0.71 | 0.78 | 64 | empty |
| 2 | 313 | 0.60 | 0.77 | 25 | empty |
| 3 | 207 | 0.46 | 0.74 | 26 | empty |
| 4 | 146 | 0.40 | 0.73 | 21 | empty |
| 5 | 132 | 0.36 | 0.72 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 556 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 1P5C · Circular permutation of Helix A in T4 lysozyme · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00720
- Elsewhere: RCSB PDB 1P5C · PDBe 1P5C · UniProt P00720
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