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CD25 in complex with Fab

Analyse CD25 in complex with Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7F9W
Type
protein
Length
547 residues
Chains
3
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Interleukin-2 receptor subunit alpha; Light chain of Fab; Heavy chain of Fab
UniProt
P01589
Pockets
5 · best druggability 0.62

Structure

electron microscopy · 3 distinct chains · 4% helix, 43% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AInterleukin-2 receptor subunit alphaprotein1060% helix, 31% strandP01589
CLight chain of Fabprotein2187% helix, 46% strand—
BHeavy chain of Fabprotein2234% helix, 44% strand—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11410.620.8628empty
21960.470.7539empty
3980.420.7716empty
41380.400.7428empty
5990.350.7418empty

Interfaces

3 interfaces between chains.

  • C–B · 1703 Ų buried · 6 hydrogen bonds · protein-protein
  • A–B · 630 Ų buried · 9 hydrogen bonds · protein-protein
  • A–C · 269 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

  • 7F9W · CD25 in complex with Fab · the same entry in another collection · chain A against A, TM-score 1.00
  • P01589 · AlphaFold monomer V2.0 prediction for interleukin-2 receptor subunit alpha (P01589) · a predicted model of the same protein · chain A against A, TM-score 0.94

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