Research workbench
Crystal structure of human soluble CLIC1 with catalytic cysteine (CYS24) in sulphonic acid form.
Analyse Crystal structure of human soluble CLIC1 with catalytic cysteine (CYS24) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F8R
- Type
- protein
- Length
- 467 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 1
- UniProt
- O00299
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride intracellular channel protein 1 | protein | 233 | 50% helix, 10% strand | O00299 |
| B | Chloride intracellular channel protein 1 | protein | 234 | 50% helix, 9% strand | O00299 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 372 | 0.69 | 0.82 | 36 | empty |
| 2 | 53 | 0.37 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 912 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 7F8R · Crystal structure of human soluble CLIC1 with catalytic cysteine (Cys24) in sulphonic… · the same entry in another collection · chain A against A, TM-score 1.00
- O00299 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 1 (O00299) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00299
- Elsewhere: RCSB PDB 7F8R · PDBe 7F8R · UniProt O00299
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