Research workbench
Cryoem structure of human KV4.2-KCHIP1 complex
Analyse Cryoem structure of human KV4.2-KCHIP1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F3F
- Type
- protein
- Length
- 2,548 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily D member 2; Isoform 2 of kv channel-interacting…
- UniProt
- Q9NZV8, Q9NZI2
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, G | Potassium voltage-gated channel subfamily D member 2 | protein | 460 | 64% helix, 5% strand | Q9NZV8 |
| E, H, J, L | Isoform 2 of kv channel-interacting protein 1 | protein | 177 | 56% helix, 4% strand | Q9NZI2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 828 | 0.82 | 0.84 | 44 | empty |
| 2 | 521 | 0.81 | 0.88 | 40 | empty |
| 3 | 1180 | 0.75 | 0.77 | 88 | empty |
| 4 | 1084 | 0.75 | 0.77 | 85 | empty |
| 5 | 1195 | 0.75 | 0.77 | 92 | empty |
Interfaces
14 interfaces between chains.
- D–G · 3454 Ų buried · 24 hydrogen bonds · protein-protein
- A–B · 3444 Ų buried · 23 hydrogen bonds · protein-protein
- B–D · 3442 Ų buried · 22 hydrogen bonds · protein-protein
- A–G · 3424 Ų buried · 21 hydrogen bonds · protein-protein
- G–E · 1811 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7F3F · CryoEM structure of human Kv4.2-KChIP1 complex · the same entry in another collection · chain L against L, TM-score 1.00
- Q9NZI2 · AlphaFold monomer V2.0 prediction for kv channel-interacting protein 1 (Q9NZI2) · a predicted model of the same protein · chain E against A, TM-score 0.86
- Q9NZV8 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZV8
- Every structure of UniProt Q9NZI2
- Elsewhere: RCSB PDB 7F3F · PDBe 7F3F · UniProt Q9NZV8 · UniProt Q9NZI2
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