Research workbench
Cryo-EM structure of the minimal protein-only RNase P from aquifex aeolicus
Analyse Cryo-EM structure of the minimal protein-only RNase P from aquifex aeolicus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F3E
- Type
- protein
- Length
- 2,256 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-free ribonuclease P
- EC
- 3.1.26.5
- UniProt
- O67035
- Pockets
- 20 · best druggability 0.68
Structure
electron microscopy · 1 distinct chain · 62% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F, C, D, A, B, H, G, J, I, L, K | RNA-free ribonuclease P (EC 3.1.26.5) | protein | 188 | 62% helix, 9% strand | O67035 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 485 | 0.68 | 0.79 | 59 | empty |
| 2 | 532 | 0.68 | 0.78 | 65 | empty |
| 3 | 320 | 0.66 | 0.81 | 42 | empty |
| 4 | 452 | 0.65 | 0.78 | 52 | empty |
| 5 | 351 | 0.64 | 0.79 | 43 | empty |
Interfaces
28 interfaces between chains.
- E–F · 2200 Ų buried · 18 hydrogen bonds · protein-protein
- H–G · 2195 Ų buried · 18 hydrogen bonds · protein-protein
- J–I · 2153 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 2151 Ų buried · 14 hydrogen bonds · protein-protein
- L–K · 2070 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7F3E · Cryo-EM structure of the minimal protein-only RNase P from Aquifex aeolicus · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67035
- Elsewhere: RCSB PDB 7F3E · PDBe 7F3E · UniProt O67035
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