Research workbench

Death associated protein kinase catalytic domain with bound inhibitor fragment

Analyse Death associated protein kinase catalytic domain with bound inhibitor fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1P4F
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Death-associated protein kinase 1
EC: 2.7.1.-
UniProt: P53355
Ligands: 86Q
Pockets: 1 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Death-associated protein kinase 1 (EC 2.7.1.-)	protein	269	35% helix, 20% strand	P53355

Ligands and binding sites

86Q · 5,6-Dihydro-benzo[H]cinnolin-3-ylamine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	447	0.67	0.79	45	86Q

Compared structures

1P4F · Death associated protein kinase catalytic domain with bound inhibitor fragment · the same entry in another collection · chain A against A, TM-score 1.00
P53355 · AlphaFold monomer V2.0 prediction for death-associated protein kinase 1 (P53355) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53355
Elsewhere: RCSB PDB 1P4F · PDBe 1P4F · UniProt P53355

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.