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Crystal structure of HSALC1

Analyse Crystal structure of HSALC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EPU
Type: protein
Length: 978 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-immunized human scfv; Chromodomain-helicase-DNA-binding protein 1-like
EC: 3.6.4.12
UniProt: Q86WJ1
Ligands: ADP, MG
Pockets: 19 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Non-immunized human scfv	protein	230	5% helix, 50% strand	—
B	Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12)	protein	748	41% helix, 11% strand	Q86WJ1

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains B
MG · Magnesium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.73	0.97	18	empty
2	610	0.73	0.80	84	ADP, MG
3	64	0.68	0.95	24	empty
4	388	0.64	0.78	36	empty
5	277	0.62	0.80	39	empty

Interfaces

1 interface between chains.

A–B · 1349 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent, 2 disulfide (covalent ligand, disulfide).

Compared structures

7EPU · Crystal structure of HsALC1 · the same entry in another collection · chain A against A, TM-score 1.00
Q86WJ1 · AlphaFold monomer V2.0 prediction for chromodomain-helicase-DNA- binding protein 1-like… · a predicted model of the same protein · chain B against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86WJ1
Elsewhere: RCSB PDB 7EPU · PDBe 7EPU · UniProt Q86WJ1

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