Research workbench
Cryo-EM structure of inactive MGLU2-7 heterodimer
Analyse Cryo-EM structure of inactive MGLU2-7 heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EPD
- Type
- protein
- Length
- 1,569 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 2,PEPTIDYLPROLYL isomerase; Isoform 3 of metabotropic…
- EC
- 5.2.1.8
- UniProt
- Q14416
- Pockets
- 19 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 42% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor 2,PEPTIDYLPROLYL isomerase (EC 5.2.1.8) | protein | 777 | 43% helix, 8% strand | Q14416 |
| B | Isoform 3 of metabotropic glutamate receptor 7 | protein | 792 | 41% helix, 9% strand | — |
Pockets
19 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1089 | 0.78 | 0.80 | 121 | empty |
| 2 | 520 | 0.76 | 0.84 | 71 | empty |
| 3 | 632 | 0.69 | 0.78 | 59 | empty |
| 4 | 50 | 0.69 | 0.97 | 15 | empty |
| 5 | 71 | 0.67 | 0.94 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1185 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 19 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14416
- Elsewhere: RCSB PDB 7EPD · PDBe 7EPD · UniProt Q14416
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.