Research workbench
The complex structure of GPSM2 and whirlin
Analyse The complex structure of GPSM2 and whirlin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EP7
- Type
- protein
- Length
- 342 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein-signaling modulator 2; Whirlin
- UniProt
- Q8VDU0, Q9P202
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-protein-signaling modulator 2 | protein | 327 | 85% helix, 0% strand | Q8VDU0 |
| B | Whirlin | protein | 15 | 0% helix, 0% strand | Q9P202 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.44 | 0.75 | 18 | empty |
| 2 | 65 | 0.34 | 0.77 | 12 | empty |
| 3 | 73 | 0.32 | 0.75 | 16 | empty |
| 4 | 50 | 0.27 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1271 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7EP7 · The complex structure of Gpsm2 and Whirlin · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VDU0 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (Q8VDU0) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q9P202 · AlphaFold monomer V2.0 prediction for whirlin (Q9P202) · a predicted model of the same protein · chain B against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VDU0
- Every structure of UniProt Q9P202
- Elsewhere: RCSB PDB 7EP7 · PDBe 7EP7 · UniProt Q8VDU0 · UniProt Q9P202
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