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The atomic structure of SHP2 E76A mutant

Analyse The atomic structure of SHP2 E76A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EMN
Type: protein
Length: 992 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11
EC: 3.1.3.48
UniProt: Q06124
Pockets: 11 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	493	28% helix, 25% strand	Q06124
B	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	499	28% helix, 25% strand	Q06124

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1113	0.73	0.76	90	empty
2	260	0.59	0.79	30	empty
3	268	0.57	0.78	32	empty
4	123	0.54	0.83	32	empty
5	101	0.48	0.81	16	empty

Interfaces

1 interface between chains.

A–B · 205 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7EMN · The atomic structure of SHP2 E76A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 7EMN · PDBe 7EMN · UniProt Q06124

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