Research workbench
Human voltage-gated potassium channel KV1.3
Analyse Human voltage-gated potassium channel KV1.3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EJ1
- Type
- protein
- Length
- 2,740 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel subunit beta-2; Potassium voltage-gated channel subfamily…
- EC
- 1.1.1.-
- UniProt
- Q13303, P22001
- Ligands
- NAP
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 2 distinct chains · 51% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) | protein | 326 | 43% helix, 14% strand | Q13303 |
| B, D, F, H | Potassium voltage-gated channel subfamily a member 3 | protein | 359 | 58% helix, 5% strand | P22001 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, C, E, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 643 | 0.85 | 0.90 | 80 | empty |
| 2 | 1045 | 0.82 | 0.83 | 102 | empty |
| 3 | 827 | 0.79 | 0.81 | 51 | empty |
| 4 | 759 | 0.77 | 0.81 | 72 | empty |
| 5 | 745 | 0.77 | 0.81 | 76 | empty |
Interfaces
18 interfaces between chains.
- B–D · 2200 Ų buried · 14 hydrogen bonds · protein-protein
- B–H · 2194 Ų buried · 14 hydrogen bonds · protein-protein
- F–H · 2190 Ų buried · 14 hydrogen bonds · protein-protein
- D–F · 2186 Ų buried · 14 hydrogen bonds · protein-protein
- C–E · 931 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7EJ1 · human voltage-gated potassium channel KV1.3 · the same entry in another collection · chain H against H, TM-score 1.00
- Q13303 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P22001 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13303
- Every structure of UniProt P22001
- Elsewhere: RCSB PDB 7EJ1 · PDBe 7EJ1 · UniProt Q13303 · UniProt P22001
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