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Recombinant rat annexin V, quadruple mutant (T72K, S144K, S228K, S303K)

Analyse Recombinant rat annexin V, quadruple mutant (T72K, S144K, S228K, S303K) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BC1
Type: protein
Length: 318 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin V
UniProt: P14668
Ligands: CA, SO4
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin V	protein	318	73% helix, 0% strand	P14668

Ligands and binding sites

CA · Calcium ion · metal · 5 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	112	0.58	0.85	27	empty
2	101	0.50	0.82	22	empty
3	107	0.38	0.75	16	empty

Compared structures

1BC1 · Recombinant rat annexin V, quadruple mutant (T72K, S144K, S228K, S303K) · the same entry in another collection · chain A against A, TM-score 1.00
P14668 · AlphaFold monomer V2.0 prediction for annexin A5 (P14668) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14668
Elsewhere: RCSB PDB 1BC1 · PDBe 1BC1 · UniProt P14668

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