Research workbench
SNF5 finger helix bound to the nucleosome
Analyse SNF5 finger helix bound to the nucleosome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EG6
- Type
- protein + DNA
- Length
- 1,071 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SWI/SNF chromatin-remodeling complex subunit SNF5; Histone H3.2; Histone H4; Histone H2A…
- UniProt
- P18480, P84233, P62799, P06897, P02281
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 9 distinct chains · 63% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | SWI/SNF chromatin-remodeling complex subunit SNF5 | protein | 18 | 78% helix, 0% strand | P18480 |
| A | Histone H3.2 | protein | 98 | 64% helix, 4% strand | P84233 |
| B | Histone H4 | protein | 82 | 60% helix, 7% strand | P62799 |
| C, G | Histone H2A type 1 | protein | 107 | 52% helix, 7% strand | P06897 |
| D, H | Histone H2B 1.1 | protein | 93 | 73% helix, 4% strand | P02281 |
| E | Histone H3.2 | protein | 95 | 66% helix, 4% strand | P84233 |
| F | Histone H4 | protein | 86 | 57% helix, 8% strand | P62799 |
| I | DNA (235-mer) | dna | 146 | — | — |
| J | DNA (235-mer) | dna | 146 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 596 | 0.77 | 0.83 | 70 | empty |
| 2 | 400 | 0.75 | 0.86 | 52 | empty |
| 3 | 431 | 0.74 | 0.84 | 41 | empty |
| 4 | 1081 | 0.72 | 0.76 | 65 | empty |
| 5 | 254 | 0.70 | 0.86 | 33 | empty |
Interfaces
38 interfaces between chains.
- I–J · 6639 Ų buried · 543 hydrogen bonds · nucleic-nucleic
- G–H · 2605 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2601 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 2591 Ų buried · 18 hydrogen bonds · protein-protein
- E–F · 2590 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18480
- Every structure of UniProt P84233
- Every structure of UniProt P62799
- Every structure of UniProt P06897
- Every structure of UniProt P02281
- Elsewhere: RCSB PDB 7EG6 · PDBe 7EG6 · UniProt P18480 · UniProt P84233 · UniProt P62799 · UniProt P06897 · UniProt P02281
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