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Macrophage migration inhibitory factor (mif) with pro-1 mutated to gly-1

Analyse Macrophage migration inhibitory factor (mif) with pro-1 mutated to gly-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1P1G
Type: protein
Length: 342 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (macrophage migration inhibitory factor)
UniProt: P14174
Pockets: 4 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Protein (macrophage migration inhibitory factor)	protein	114	39% helix, 31% strand	P14174

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	663	0.82	0.86	69	empty
2	51	0.48	0.85	12	empty
3	72	0.46	0.82	18	empty
4	76	0.46	0.81	16	empty

Interfaces

3 interfaces between chains.

A–B · 1178 Å² buried · 19 hydrogen bonds · protein-protein
B–C · 1178 Å² buried · 17 hydrogen bonds · protein-protein
A–C · 1176 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1P1G · Macrophage migration inhibitory factor (mif) with pro-1 mutated to gly-1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14174
Elsewhere: RCSB PDB 1P1G · PDBe 1P1G · UniProt P14174

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