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Crystal structure of human FABP7 complexed with palmitic acid

Analyse Crystal structure of human FABP7 complexed with palmitic acid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E25
Type: protein
Length: 139 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid-binding protein, brain
UniProt: O15540
Ligands: PLM, SO4
Pockets: 1 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty acid-binding protein, brain	protein	139	15% helix, 55% strand	O15540

Ligands and binding sites

PLM · Palmitic acid · ligand · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	340	0.86	0.95	34	GOL, PLM

Compared structures

7E25 · Crystal structure of human FABP7 complexed with palmitic acid · the same entry in another collection · chain A against A, TM-score 1.00
O15540 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, brain (O15540) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15540
Elsewhere: RCSB PDB 7E25 · PDBe 7E25 · UniProt O15540

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