Research workbench

Human bile salt exporter ABCB11 in complex with taurocholate

Analyse Human bile salt exporter ABCB11 in complex with taurocholate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E1A
Type: protein
Length: 1,189 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bile salt export pump
EC: 7.6.2.-
UniProt: O95342
Ligands: TCH
Pockets: 15 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 39% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	Bile salt export pump (EC 7.6.2.-)	protein	1189	39% helix, 4% strand	O95342

Ligands and binding sites

TCH · Taurocholic acid · ligand · chains U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1096	0.84	0.85	85	TCH
2	167	0.70	0.89	30	empty
3	51	0.69	0.97	19	empty
4	260	0.58	0.79	31	empty
5	73	0.55	0.87	17	empty

Compared structures

7E1A · Human bile salt exporter ABCB11 in complex with taurocholate · the same entry in another collection · chain U against U, TM-score 1.00
O95342 · AlphaFold monomer V2.0 prediction for bile salt export pump (O95342) · a predicted model of the same protein · chain U against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95342
Elsewhere: RCSB PDB 7E1A · PDBe 7E1A · UniProt O95342

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