UniProt O95342
Bile salt export pump (O95342)
Bile salt export pump (UniProt O95342), EC 7.6.2.-: 9 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 75 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95342
- Protein
- Bile salt export pump
- EC
- 7.6.2.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 75 · 5 records with a druggable one
Structures
10 records of O95342 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LR0 | structure of human bile salt exporter ABCB11 | electron microscopy | U | — | — |
| 6LR0 | Structure of human bile salt exporter ABCB11 | electron microscopy | U | — | — |
| 7DV5 | Human bile salt exporter ABCB11 in complex with taurocholate | electron microscopy | U | TCH | 16 (best 0.86) |
| 7DV5 | Human bile salt exporter ABCB11 in complex with taurocholate | electron microscopy | U | TCH | — |
| 7E1A | Human bile salt exporter ABCB11 in complex with taurocholate | electron microscopy | U | TCH | 15 (best 0.84) |
| 7E1A | Human bile salt exporter ABCB11 in complex with taurocholate | electron microscopy | U | TCH | — |
| 8PM6 | Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs | electron microscopy | A | CLR, GBM | 9 (best 0.81) |
| 8PMD | Nucleotide-bound BSEP in nanodiscs | electron microscopy | A | ATP, MG | 18 (best 0.89) |
| 8PMJ | Vanadate-trapped BSEP in nanodiscs | electron microscopy | A | ATP, CLR, ADP, VO4, MG | 17 (best 0.89) |
| O95342 | AlphaFold monomer V2.0 prediction for bile salt export pump (O95342) | predicted | A | — | — |
Ligands
- TCH · Taurocholic acid · in 4 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- CLR · Cholesterol · in 2 records
- MG · Magnesium ion · in 2 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · in 1 record
- VO4 · Vanadate ion · in 1 record
Experiment against prediction
- 7E1A chain U against the predicted model O95342: TM-score 0.95, RMSD 2.66 Å
- 7E1A chain U against the predicted model O95342: TM-score 0.95, RMSD 2.66 Å
- 8PM6 chain A against the predicted model O95342: TM-score 0.95, RMSD 2.46 Å
- 7DV5 chain U against the predicted model O95342: TM-score 0.93, RMSD 3.19 Å
- 7DV5 chain U against the predicted model O95342: TM-score 0.93, RMSD 3.19 Å
- 6LR0 chain U against the predicted model O95342: TM-score 0.90, RMSD 3.66 Å
- 6LR0 chain U against the predicted model O95342: TM-score 0.90, RMSD 3.66 Å
- 8PMD chain A against the predicted model O95342: TM-score 0.69, RMSD 7.41 Å
- 8PMJ chain A against the predicted model O95342: TM-score 0.69, RMSD 7.54 Å
Elsewhere
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