Structure of TRPC3 at 3.06 ångström in low calcium state

Structure

electron microscopy · 1 distinct chain · 66% helix, 0% strand (DSSP).

Ligands and binding sites

• Y01 · Cholesterol hemisuccinate · ligand · 8 copies · chains A, B, D, C
• 98R · [(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate · ligand · 4 copies · chains A, B, D, C
• POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 4 copies · chains A, C, B, D
• ZN · Zinc ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Interfaces

6 interfaces between chains.

• B–D · 3346 Ų buried · 18 hydrogen bonds · protein-protein
• A–B · 3342 Ų buried · 18 hydrogen bonds · protein-protein
• A–C · 3338 Ų buried · 18 hydrogen bonds · protein-protein
• C–D · 3335 Ų buried · 18 hydrogen bonds · protein-protein
• B–C · 41 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 7DXC · Structure of TRPC3 at 3.06 angstrom in low calcium state · the same entry in another collection · chain A against A, TM-score 1.00
• Q13507 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 3… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13507
• Elsewhere: RCSB PDB 7DXC · PDBe 7DXC · UniProt Q13507