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Human annexin A2 with C132-C261 intramolecular disulfide bond

Analyse Human annexin A2 with C132-C261 intramolecular disulfide bond in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DTO
Type: protein
Length: 308 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A2
UniProt: P07355
Pockets: 3 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A2	protein	308	72% helix, 0% strand	P07355

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	97	0.53	0.84	25	empty
2	88	0.48	0.82	22	empty
3	51	0.27	0.74	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7DTO · Human Annexin A2 with C132-C261 intramolecular disulfide bond · the same entry in another collection · chain A against A, TM-score 1.00
P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07355
Elsewhere: RCSB PDB 7DTO · PDBe 7DTO · UniProt P07355

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