Research workbench
Crystal structure of actin capping protein in complex with twinflin-2 C-terminus tail
Analyse Crystal structure of actin capping protein in complex with twinflin-2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DS3
- Type
- protein
- Length
- 519 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q9Z0P5
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 266 | 40% helix, 34% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 | protein | 234 | 40% helix, 36% strand | P14315 |
| C | Twinfilin-2 | protein | 19 | 0% helix, 0% strand | Q9Z0P5 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 515 | 0.77 | 0.84 | 60 | empty |
| 2 | 114 | 0.40 | 0.76 | 23 | empty |
| 3 | 71 | 0.39 | 0.79 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 3623 Ų buried · 61 hydrogen bonds · protein-protein
- B–C · 1175 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7DS3 · Crystal structure of actin capping protein in complex with twinflin-2 C-terminus tail · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.94
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q9Z0P5 · AlphaFold monomer V2.0 prediction for twinfilin-2 (Q9Z0P5) · a predicted model of the same protein · chain C against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q9Z0P5
- Elsewhere: RCSB PDB 7DS3 · PDBe 7DS3 · UniProt P13127 · UniProt P14315 · UniProt Q9Z0P5
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