Research workbench
1.5A crystal structure of the nogo receptor ligand binding domain reveals a convergent recognition scaffold mediating inhibition of myelination
Analyse 1.5A crystal structure of the nogo receptor ligand binding domain reveals a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OZN
- Type
- protein
- Length
- 284 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reticulon 4 receptor
- UniProt
- Q9BZR6
- Ligands
- NAG, NDG, MAN, BMA
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reticulon 4 receptor | protein | 284 | 9% helix, 18% strand | Q9BZR6 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · sugar · 2 copies
- MAN · alpha-D-mannopyranose · sugar · 2 copies
- BMA · beta-D-mannopyranose · sugar
- ACY · Acetic acid · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 1OZN · 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BZR6 · AlphaFold monomer V2.0 prediction for reticulon-4 receptor (Q9BZR6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BZR6
- Elsewhere: RCSB PDB 1OZN · PDBe 1OZN · UniProt Q9BZR6
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