Research workbench
Crystal structure of FGFR3 in complex with pyrimidine derivative
Analyse Crystal structure of FGFR3 in complex with pyrimidine derivative in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DHL
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 3
- EC
- 2.7.10.1
- UniProt
- P22607
- Ligands
- H6X
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 3 (EC 2.7.10.1) | protein | 289 | 38% helix, 18% strand | P22607 |
Ligands and binding sites
- H6X · 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 447 | 0.71 | 0.81 | 48 | H6X |
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 7DHL · Crystal structure of FGFR3 in complex with pyrimidine derivative · the same entry in another collection · chain A against A, TM-score 1.00
- P22607 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 3 (P22607) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22607
- Elsewhere: RCSB PDB 7DHL · PDBe 7DHL · UniProt P22607
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.