UniProt P22607
Fibroblast growth factor receptor 3 (P22607)
Fibroblast growth factor receptor 3 (UniProt P22607), EC 2.7.10.1: 14 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22607
- Protein
- Fibroblast growth factor receptor 3
- EC
- 2.7.10.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 47 · 5 records with a druggable one
Structures
15 records of P22607 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RY7 | Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1 | x-ray diffraction | B | — | — |
| 1RY7 | Crystal structure of the 3 ig form of FGFR3C in complex with FGF1 | x-ray diffraction | B | — | — |
| 2LZL | FGFR3tm | solution nmr | A, B | — | — |
| 2LZL | FGFR3TM | solution nmr | A, B | — | — |
| 4K33 | Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a… | x-ray diffraction | A | — | — |
| 4K33 | Crystal structure of FGF receptor 3 (FGFR3) kinase domain harboring the K650E mutation, a… | x-ray diffraction | A | — | — |
| 6LVM | Crystal structure of FGFR3 in complex with pyrimidine derivative | x-ray diffraction | A | EVR | — |
| 6PNX | Crystal structure of an asymmetric dimer of FGF receptor 3 kinases trapped in a-loop tyrosine… | x-ray diffraction | A, B | ACP, SO4 | — |
| 7DHL | Crystal structure of FGFR3 in complex with pyrimidine derivative | x-ray diffraction | A | H6X | — |
| 7YSU | Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | electron microscopy | C, E | SGN, IDS, CU | 9 (best 0.75) |
| 8UDT | The X-RAY co-crystal structure of human FGFR3 and KIN-3248 | x-ray diffraction | A, B, C | MLT, WGF | 11 (best 0.81) |
| 8UDU | The X-RAY co-crystal structure of human FGFR3 and Compound 17 | x-ray diffraction | A, B | CL, WIQ | 5 (best 0.73) |
| 8UDV | The X-RAY co-crystal structure of human FGFR3 V555M and Compound 17 | x-ray diffraction | A, B, C | SO4, WIQ | 13 (best 0.83) |
| 9CD7 | FGFR3 Kinase Domain with Inhibitor TYRA-300 | x-ray diffraction | A, B, C | A1AV2, SO4 | 9 (best 0.83) |
| P22607 | AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 3 (P22607) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 3 records
- WIQ · 3-[(6-chloro-1-cyclopropyl-1H-benzimidazol-5-yl)ethynyl]-1-[(3S,5S)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide · in 2 records
- A1AV2 · (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole · in 1 record
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
- CL · Chloride ion · in 1 record
- CU · Copper (II) ion · in 1 record
- EVR · 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-N-ethyl-benzenesulfonamide · in 1 record
- H6X · 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine · in 1 record
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 1 record
- MLT · D-malate · in 1 record
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 1 record
- WGF · 3-[(1-cyclopropyl-4,6-difluoro-1H-benzimidazol-5-yl)ethynyl]-1-[(3R,5R)-5-(methoxymethyl)-1-propanoylpyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide · in 1 record
Experiment against prediction
- 8UDU chain B against the predicted model P22607: TM-score 0.98, RMSD 1.03 Å
- 6LVM chain A against the predicted model P22607: TM-score 0.97, RMSD 1.35 Å
- 7DHL chain A against the predicted model P22607: TM-score 0.97, RMSD 1.42 Å
- 4K33 chain A against the predicted model P22607: TM-score 0.96, RMSD 1.55 Å
- 4K33 chain A against the predicted model P22607: TM-score 0.96, RMSD 1.55 Å
- 8UDV chain C against the predicted model P22607: TM-score 0.95, RMSD 1.60 Å
- 9CD7 chain A against the predicted model P22607: TM-score 0.94, RMSD 1.78 Å
- 9CD7 chain B against the predicted model P22607: TM-score 0.93, RMSD 1.83 Å
- 9CD7 chain C against the predicted model P22607: TM-score 0.93, RMSD 1.83 Å
- 6PNX chain B against the predicted model P22607: TM-score 0.93, RMSD 1.88 Å
Elsewhere
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