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Ligand · A1AV2

A1AV2 · (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole

A1AV2, (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole (C25 H24 Cl2 N6 O3 S, 559.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB…

Component
A1AV2
Formula
C25 H24 Cl2 N6 O3 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

A1AV2 in 2 structures; the first of them:

  • 9CD5 · FGFR1 Kinase Domain Soak with Inhibitor TYRA-300 · A1AV2 A903 · binds LEU484, GLY485, VAL492, ALA512, VAL561, GLU562, TYR563, ALA564 and 10 more
  • 9CD7 · FGFR3 Kinase Domain with Inhibitor TYRA-300 · A1AV2 A801 · binds LEU478, GLY479, GLU480, GLY481, VAL486, ALA506, LYS508, ILE539 and 15 more

Residues it binds most

ALA 5, GLU 5, GLY 5, ASN 5, LEU 5, VAL 5, LYS 5, ARG 5, ASP 5, TYR 5 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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