Research workbench
Crystal structure of HSF2 DNA-binding domain in complex with 2-site hse DNA in the head-to-head orientation
Analyse Crystal structure of HSF2 DNA-binding domain in complex with 2-site hse DNA in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DCI
- Type
- protein + DNA
- Length
- 105 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock factor protein 2; DNA (5'-D(*GP*GP*GP*AP*AP*TP*AP*TP*TP*CP*CP*C)-3')
- UniProt
- Q03933
- Ligands
- NA
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock factor protein 2 | protein | 93 | 45% helix, 13% strand | Q03933 |
| B | DNA (5'-D(*GP*GP*GP*AP*AP*TP*AP*TP*TP*CP*CP*C)-3') | dna | 12 | — | — |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.44 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 247 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 7DCI · Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q03933 · AlphaFold monomer V2.0 prediction for heat shock factor protein 2 (Q03933) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03933
- Elsewhere: RCSB PDB 7DCI · PDBe 7DCI · UniProt Q03933
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