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Crystal structure of the myrf ica domain

Analyse Crystal structure of the myrf ica domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7DC3
Type: protein
Length: 427 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform 2 of myelin regulatory factor
EC: 3.4.-.-
UniProt: Q3UR85
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 44% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 2 of myelin regulatory factor (EC 3.4.-.-)	protein	147	43% helix, 16% strand	Q3UR85
B	Isoform 2 of myelin regulatory factor (EC 3.4.-.-)	protein	138	46% helix, 14% strand	Q3UR85
C	Isoform 2 of myelin regulatory factor (EC 3.4.-.-)	protein	142	44% helix, 14% strand	Q3UR85

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1194	0.71	0.75	81	empty
2	469	0.59	0.73	40	empty
3	165	0.41	0.73	25	empty

Interfaces

2 interfaces between chains.

A–B · 344 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 101 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

7DC3 · Crystal structure of the MyRF ICA domain · the same entry in another collection · chain A against A, TM-score 1.00
Q3UR85 · AlphaFold monomer V2.0 prediction for myelin regulatory factor (Q3UR85) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3UR85
Elsewhere: RCSB PDB 7DC3 · PDBe 7DC3 · UniProt Q3UR85

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