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DNA binding domain of human DNA ligase IV - wild type

Analyse DNA binding domain of human DNA ligase IV - wild type in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7D9K
Type: protein
Length: 218 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA ligase 4
EC: 6.5.1.1
UniProt: P49917
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA ligase 4 (EC 6.5.1.1)	protein	218	63% helix, 2% strand	P49917

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.38	0.76	22	empty
2	78	0.35	0.75	12	empty

Compared structures

7D9K · DNA binding domain of human DNA Ligase IV - Wild type · the same entry in another collection · chain A against A, TM-score 1.00
P49917 · AlphaFold monomer V2.0 prediction for DNA ligase 4 (P49917) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49917
Elsewhere: RCSB PDB 7D9K · PDBe 7D9K · UniProt P49917

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