UniProt P49917
DNA ligase 4 (P49917)
DNA ligase 4 (UniProt P49917), EC 6.5.1.1: 36 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49917
- Protein
- DNA ligase 4
- EC
- 6.5.1.1
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 4 · 0 records with a druggable one
Structures
37 records of P49917 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IK9 | Crystal structure of a XRCC4-DNA ligase IV complex | x-ray diffraction | C | — | — |
| 1IK9 | Crystal structure of a XRCC4-DNA ligase IV complex | x-ray diffraction | C | — | — |
| 2E2W | Solution structure of the first BRCT domain of human DNA ligase IV | solution nmr | A | — | — |
| 2E2W | Solution structure of the first brct domain of human DNA ligase IV | solution nmr | A | — | — |
| 3II6 | Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV. | x-ray diffraction | X, Y | — | — |
| 3II6 | Structure of human XRCC4 in complex with the tandem brct domains of DNA ligaseiv. | x-ray diffraction | X, Y | — | — |
| 3VNN | Crystal Structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA… | x-ray diffraction | A | — | — |
| 3VNN | Crystal structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA… | x-ray diffraction | A | — | — |
| 3W1B | Crystal Structure of Human DNA ligase IV-Artemis Complex (Mercury Derivative) | x-ray diffraction | A | — | — |
| 3W1B | Crystal structure of human DNA ligase IV-artemis complex (mercury derivative) | x-ray diffraction | A | — | — |
| 3W1G | Crystal Structure of Human DNA ligase IV-Artemis Complex (Native) | x-ray diffraction | A | — | — |
| 3W1G | Crystal structure of human DNA ligase IV-artemis complex (native) | x-ray diffraction | A | — | — |
| 3W5O | Crystal Structure of Human DNA ligase IV | x-ray diffraction | A, B | — | — |
| 3W5O | Crystal structure of human DNA ligase IV | x-ray diffraction | A, B | — | — |
| 4HTO | Crystal structure of the DBD domain of human DNA ligase IV Apo form | x-ray diffraction | A | — | — |
| 4HTO | Crystal structure of the dbd domain of human DNA ligase IV apo form | x-ray diffraction | A | — | — |
| 4HTP | Crystal structure of the DBD domain of human DNA ligase IV bound to Artemis peptide | x-ray diffraction | A, B | — | — |
| 4HTP | Crystal structure of the dbd domain of human DNA ligase IV bound to artemis peptide | x-ray diffraction | A, B | — | — |
| 6BKF | Lysyl-adenylate form of human LigIV catalytic domain with bound DNA substrate in open conformation | x-ray diffraction | A | AMP | — |
| 6BKF | Lysyl-adenylate form of human ligiv catalytic domain with bound DNA substrate in open conformation | x-ray diffraction | A | AMP | — |
| 6BKG | Human ligiv catalytic domain with bound DNA-adenylate intermediate in closed conformation | x-ray diffraction | A | CL, NA | — |
| 7D9K | DNA binding domain of human DNA Ligase IV - Wild type | x-ray diffraction | A | — | 2 (best 0.38) |
| 7D9K | DNA binding domain of human DNA ligase IV - wild type | x-ray diffraction | A | — | — |
| 7D9Y | DNA binding domain of human DNA Ligase IV mutant - A3V | x-ray diffraction | A | — | 2 (best 0.43) |
| 7D9Y | DNA binding domain of human DNA ligase IV mutant - A3V | x-ray diffraction | A | — | — |
| 7LSY | Nhej short-range synaptic complex | electron microscopy | X, Y | — | — |
| 7LT3 | NHEJ Long-range synaptic complex | electron microscopy | X, Y | — | — |
| 7LT3 | Nhej long-range synaptic complex | electron microscopy | X, Y | — | — |
| 7NFC | Cryo-EM structure of NHEJ super-complex (dimer) | electron microscopy | M, P | — | — |
| 7NFC | Cryo-EM structure of nhej super-complex (dimer) | electron microscopy | M, P | — | — |
| 7NFE | Cryo-EM structure of NHEJ super-complex (monomer) | electron microscopy | J | — | — |
| 7NFE | Cryo-EM structure of nhej super-complex (monomer) | electron microscopy | J | — | — |
| 8BHV | DNA-PK XLF mediated dimer bound to PAXX | electron microscopy | M, P | — | — |
| 8BHY | DNA-PK Ku80 mediated dimer bound to PAXX and XLF | electron microscopy | I, R | — | — |
| 8BOT | Cryo-EM structure of NHEJ supercomplex(trimer) | electron microscopy | M, P | — | — |
| 8EZA | NHEJ Long-range complex with PAXX | electron microscopy | X, Y | — | — |
| P49917 | AlphaFold monomer V2.0 prediction for DNA ligase 4 (P49917) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6BKG chain A against the predicted model P49917: TM-score 0.99, RMSD 0.68 Å
- 4HTP chain A against the predicted model P49917: TM-score 0.98, RMSD 0.99 Å
- 4HTP chain A against the predicted model P49917: TM-score 0.98, RMSD 0.99 Å
- 4HTP chain B against the predicted model P49917: TM-score 0.98, RMSD 0.96 Å
- 4HTP chain B against the predicted model P49917: TM-score 0.98, RMSD 0.96 Å
- 3VNN chain A against the predicted model P49917: TM-score 0.91, RMSD 1.45 Å
- 3VNN chain A against the predicted model P49917: TM-score 0.91, RMSD 1.45 Å
- 2E2W chain A against the predicted model P49917: TM-score 0.89, RMSD 1.36 Å
- 2E2W chain A against the predicted model P49917: TM-score 0.89, RMSD 1.36 Å
- 4HTO chain A against the predicted model P49917: TM-score 0.86, RMSD 2.13 Å
Elsewhere
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