Research workbench

Human potassium-chloride co-transporter KCC2

Analyse Human potassium-chloride co-transporter KCC2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7D8Z
Type: protein
Length: 1,790 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium-chloride cotransporter 2
UniProt: Q9H2X9
Ligands: NAG
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 52% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Potassium-chloride cotransporter 2	protein	895	52% helix, 10% strand	Q9H2X9

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	168	0.81	0.96	39	empty
2	1090	0.81	0.82	103	empty
3	151	0.80	0.96	39	empty
4	711	0.75	0.81	59	empty
5	819	0.73	0.78	66	empty

Interfaces

1 interface between chains.

B–A · 3436 Å² buried · 32 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide, 6 glycan (disulfide, N-glycosylation).

Compared structures

7D8Z · human potassium-chloride co-transporter KCC2 · the same entry in another collection · chain B against B, TM-score 1.00
Q9H2X9 · AlphaFold monomer V2.0 prediction for solute carrier family 12 member 5 (Q9H2X9) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H2X9
Elsewhere: RCSB PDB 7D8Z · PDBe 7D8Z · UniProt Q9H2X9

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