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Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)

Analyse Complex between YPD1 and SLN1 response regulator domain in space group… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1OXB
Type
protein
Length
290 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
YPD1P; SLN1
EC
2.7.3.-
UniProt
Q07688, P39928
Ligands
SO4
Pockets
2 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 8% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AYPD1Pprotein16662% helix, 0% strandQ07688
BSLN1 (EC 2.7.3.-)protein12443% helix, 19% strandP39928

Ligands and binding sites

  • SO4 · Sulfate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1960.440.7919empty
2690.390.7917SO4

Interfaces

1 interface between chains.

  • A–B · 1001 Ų buried · 20 hydrogen bonds · protein-protein

Compared structures

  • 1OXB · Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1) · the same entry in another collection · chain A against A, TM-score 1.00
  • P39928 · AlphaFold monomer V2.0 prediction for osmosensing histidine protein kinase SLN1 (P39928) · a predicted model of the same protein · chain B against A, TM-score 0.98
  • Q07688 · AlphaFold monomer V2.0 prediction for phosphorelay intermediate protein YPD1 (Q07688) · a predicted model of the same protein · chain A against A, TM-score 0.96

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