Research workbench
RNA methyltransferase METTL4
Analyse RNA methyltransferase METTL4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CV9
- Type
- protein
- Length
- 707 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyltransferase-like protein 2
- EC
- 2.1.1.-
- UniProt
- Q8LFA9
- Ligands
- SAH
- Pockets
- 10 · best druggability 0.88
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Methyltransferase-like protein 2 (EC 2.1.1.-) | protein | 351 | 29% helix, 26% strand | Q8LFA9 |
| A | Methyltransferase-like protein 2 (EC 2.1.1.-) | protein | 356 | 29% helix, 24% strand | Q8LFA9 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains C, A
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1025 | 0.88 | 0.89 | 127 | SAH, GOL |
| 2 | 232 | 0.70 | 0.86 | 34 | empty |
| 3 | 164 | 0.55 | 0.81 | 31 | empty |
| 4 | 111 | 0.45 | 0.78 | 22 | empty |
| 5 | 68 | 0.42 | 0.80 | 18 | empty |
Interfaces
1 interface between chains.
- C–A · 1524 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8LFA9
- Elsewhere: RCSB PDB 7CV9 · PDBe 7CV9 · UniProt Q8LFA9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.