Research workbench
Crystal structure of fission yeast CCQ1 and TPZ1
Analyse Crystal structure of fission yeast CCQ1 and TPZ1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CUJ
- Type
- protein
- Length
- 588 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coiled-coil quantitatively-enriched protein 1; Protection of telomeres protein TPZ1
- UniProt
- Q10432, O14246
- Pockets
- 6 · best druggability 0.48
Structure
x-ray diffraction · 4 distinct chains · 55% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coiled-coil quantitatively-enriched protein 1 | protein | 258 | 53% helix, 12% strand | Q10432 |
| C | Protection of telomeres protein TPZ1 | protein | 38 | 66% helix, 3% strand | O14246 |
| B | Coiled-coil quantitatively-enriched protein 1 | protein | 256 | 54% helix, 13% strand | Q10432 |
| D | Protection of telomeres protein TPZ1 | protein | 36 | 58% helix, 3% strand | O14246 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.48 | 0.75 | 27 | empty |
| 2 | 84 | 0.41 | 0.79 | 21 | empty |
| 3 | 73 | 0.39 | 0.79 | 19 | empty |
| 4 | 53 | 0.29 | 0.75 | 14 | empty |
| 5 | 63 | 0.29 | 0.73 | 12 | empty |
Interfaces
5 interfaces between chains.
- A–C · 996 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 927 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 763 Ų buried · 10 hydrogen bonds · protein-protein
- C–B · 737 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 511 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7CUJ · Crystal structure of fission yeast Ccq1 and Tpz1 · the same entry in another collection · chain D against D, TM-score 1.00
- Q10432 · AlphaFold monomer V2.0 prediction for coiled-coil quantitatively- enriched protein 1… · a predicted model of the same protein · chain B against A, TM-score 0.95
- O14246 · AlphaFold monomer V2.0 prediction for protection of telomeres protein TPZ1 (O14246) · a predicted model of the same protein · chain C against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q10432
- Every structure of UniProt O14246
- Elsewhere: RCSB PDB 7CUJ · PDBe 7CUJ · UniProt Q10432 · UniProt O14246
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