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Complex structure of hppd with topramezone

Analyse Complex structure of hppd with topramezone in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CQS
Type: protein
Length: 380 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4-hydroxyphenylpyruvate dioxygenase
EC: 1.13.11.27
UniProt: P93836
Ligands: GJL, CO
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)	protein	380	27% helix, 34% strand	P93836

Ligands and binding sites

GJL · 4-[3-(4,5-dihydro-1,2-oxazol-3-yl)-2-methyl-4-methylsulfonyl-phenyl]carbonyl-2-methyl-1~{H}-pyrazol-3-one · ligand · chains A
CO · Cobalt (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	434	0.69	0.80	41	GJL
2	61	0.33	0.77	12	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7CQS · Complex structure of HPPD with Topramezone · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt P93836
Elsewhere: RCSB PDB 7CQS · PDBe 7CQS · UniProt P93836

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